Inherited Cardiac Disease

Many heart conditions are inherited and if not diagnosed and managed appropriately place the patient at risk of blackouts, weakening of the heart, or sudden death.While individually uncommon, inherited diseases of the cardiovascular system collectively represent a major health burden. Current recommendations suggest that individuals and families affected by inherited cardiovascular diseases should have access to specialist care in the form of multidisciplinary teams, with particular knowledge and experience in the diagnosis and management of these conditions. As a result, multidisciplinary services for inherited cardiovascular diseases, involving cardiologists, clinical geneticists, specialist nurses and genetic counsellors, are being developed throughout Europe. Inherited Cardiac Disease provides healthcare specialists involved in the diagnosis and treatment of inherited cardiovascular disorders with a clinically relevant summary of genetic diseases and readily accessible information that can be used in everyday practice. Containing summaries of most common inherited cardiovascular disorders and describing cardiomyopathies, inherited arrhythmia syndromes, and other inherited cardiovascular syndromes with a focus on aetiology, presentation and management, it also provides the non-specialist with a detailed knowledge of inherited cardiovascular diseases, from the fundamentals of molecular biology and genetic testing to the detailed clinical information relevant to patient management. This handbook is an excellent guide to the diagnosis and treatment of common cardiovascular disorders that should appeal not only to specialists in Inherited Cardiac Conditions, but also to less experienced readers who will almost certainly encounter patients in whom genetic factors are important. Professor William McKenna, President of the Association of Inherited Cardiac Conditions, from the preface1. Introduction ; 2. General principles of medical genetics ; 3. Genetic laboratory techniques ; 4. Genetic counselling ; 5. Genetic testing and genetic screening ; 6. Congenital heart disease ; 7. Cardiovascular manifestations in chromosomal disorders ; 8. Cardiomyopathies ; 9. Inherited arrhythmias and conduction disorders ; 10. Inherited disorders of connective tissue ; 11. Familial hypercholesterolaemia ; 12. Coronary artery disease and myocardial infarction ; 13. Stroke ; 14. Pulmonary arterial hypertension ; 15. Hereditary Haemorrhagic Telangiectasia (HHT) ; 16. Cardiac manifestations in inherited skeletal muscle disease ; 17. Mitochondrial disease ; 18. Cardiovascular disorders and inherited metabolic disease ; 19. The heart and inherited haematological disorders ; 20. Therapeutic approaches in cardiovascular genetics