Molecular Biology of the Gene

The classic textbook in molecular biology, updated with new chapters, new information, and new media. Completely up-to-date with the latest research advances, the Sixth Edition of James D. Watson's classic text, Molecular Biology of the Gene retains the distinctive character of earlier editions that has made it the most widely used book in molecular biology. Twenty-two concise chapters, co-authored by six highly respected biologists, provide current, authoritative coverage of an exciting, fast-changing discipline. Two new chapters discuss the emerging research fields of Regulatory RNAs (Chapter 18) and Genomics and Systems Biology (Chapter 20), and give particular focus on RNAi, microRNAs, the opportunities offered by the new generation of genome technologies, and the elucidation of gene regulatory networks. Every chapter includes thorough content updates, and where relevant, the inclusion of medical insights that have emerged from our understanding of basic molecular biology, and references that direct students to explore the expanded companion website.PART 1 Chemistry and Genetics 1 Mendelian View of the World 2 Nucleic Acids Convey Genetic Information 3 The Importance of Weak Chemical Interactions 4 The Importance of High Energy Bonds 5 Weak and Strong Bonds Determine Macromolecular Interactions PART 2 Maintenance of the Genome 6 The Structures of DNA and RNA 7 Genome Structure, Chromatin and the Nucleosome 8 DNA replication 9 The Mutability and Repair of DNA 10 Homologous Recombination at the Molecular Level 11 Site-Specific Recombination and Transposition of DNA PART 3 Expression of the Genome 12 Mechanisms of Transcription 13 Splicing 14 Translation PART 4 Regulation 15 The Genetic Code 16 Transcriptional Regulation in Prokaryotes 17 Transcriptional Regulation in Eukaryotes 18 Regulatory RNAs 19 Gene Regulation in Development and Evolution 20 Genomics and Systems Biology PART 5 Methods 21 Techniques of Molecular Biology 22 Model Organisms