Genomic Imprinting

Originally published in 1995, this significant publication on genomic or parental imprinting was prepared by an outstanding team of international authorities. Genomic imprinting results in the preferential expression of one allele, depending on the parent of origin. It is associated with several disease syndromes in humans. Interest in this area has expanded rapidly from the time when it was first recognised that some aspects of inheritance were not adequately explained by the Mendelian laws. The chapters cover a wealth of material to help explain not only the mechanisms of genomic imprinting but also its biological and medical consequences. This interdisciplinary volume encompasses clinical genetics, pathology, developmental biology, evolution and genetics. It will be of interest to all scientists and clinicians working in this area. Review of the hardback: '... a fully referenced and authoritative source for those who wish to understand the key issues of genomic imprinting ... this could prove an excellent start ... genomic (gametic) imprinting is not just a curiosity that is going to 'go away'; it goes to the very heart of the regulation of gene expression. This 1994 Nobel Symposium collection of papers is a first rate base from which to read some of the more recent papers ... and then follow the story unfold'. Marcus Pembrey, Journal of Medical Ethics Review of the hardback: '... a valuable resource for everyone interested in the field of genomic imprinting'. K. Devriendt, Genetic Counselling Review of the hardback: '... good to have on your bookshelf if your laboratory or institution has an interest in imprinting, as a quick reference to a rapidly expanding field'. Keith Brown, Heredity Review of the hardback: '... a good introduction to the subject'. Carmen SapienzaContributors; Part I. Genomic Imprinting in Mammals: 1. The role of imprinting in early mammalian development A. Gilligan, and D. Solter; 2. The evolution of parental imprinting: a review of hypotheses D. Haig and R. Trivers; 3. Genetic variations in parental imprinting on mouse chromosome 17 J. Forejt, S. Gregorov..., M. Landikova, J. Capkova and L. M. Silver; Part II. Chromatin Structure and DNA Modifications: 4. Epigenetic inheritance: the chromatin connection A. P. Wolffe; 5. Chromobox genes and the molecular mechanisms of cellular determination P. B. Singh and T. C. James; 6. The biochemical basis of allele-specific gene expression in genomic imprinting and X inactivation T. H. Bestor; 7. DNA methylation and mammalian development R. Jaenisch, C. Beard and E. Li; Part III. Mechanisms of Imprinting: 8. X chromosome inactivation and imprinting M. F. Lyon; 9. Imprinting of H19 and Xist in uniparental embryos M. A. Surani, A. C. Ferguson-Smith, H. Sasaki and S. C. Barton; 10. Imprinted genes, allelic methylation, and imprinted modifiers of methylation W. Reik, R. Feil, N. D. Allen, T. F. Moore and J. Walter; 11. Genomic imprinting of the H19 and Igf2 genes in the mouse S. M. Tilgham, M. S. Bartolomei, A. L. Webber, M. E. Brunkow, J. Saam, P. A. Leighton and K. Pfeifer; 12. Plasticity of imprinting R. Ohlsson, T. Ekstrom, G. Franklin, S. Pfeifer-Ohlsson, H. Cui, S. Miller, R. Fisher and C. Walsh; 13. Regional regulation of allele-specific gene expression I. Simon and H. Cedar; Part IV. Genomic Imprinting in Embryonal Tumors and Overgrowth Disorders: 14. Genomic imprinting in embryonal tumors and overgrowth disorders A. E. Reeve; 15. Tracking imprinting: the Beckwith-Wiedemann syndrome M. Mannens; 16. Genomic imprinting in Beckwith-Wiedemann syndrome R. Weksberg and J. Squire; 17. Mitotic crossing over and the disruption of genomic imprinting G. B. Cote; 18. Evaluating H19 as an imprinted tumor suppressor gene B. Tycko; 19. A domain of abnormal imprinting in human cancer A. P. Feinberg; Part V. Genomic Imprinting and the Prader-Willi Syndrome: 20. Parent-of-origin-specific DNA methylation and imprinting mutations on human chromosome 15 B. Horsthemke, B. Dittrich and K. Buiting; 21. The SNRPN gene and Prader-Willi syndrome U. Francke, J. A. Kerns and J. Giacalone; Part VI. Imprinting: A Search for New Genes and Unifying Principles: 22. Use of chromosome rearrangements for investigations into imprinting in the mouse B. M. Cattanach, J. Barr and J. Jones; 23. A new imprinted gene, U2af-related sequence, isolated by a methylation-sensitive genome scanning method T. Mukai, I. Hatada, T. Yamaoka, K. Kitagawa, X.-D. Wang, T. Sugama, J. Masuda and J. Ogata; 24. The mouse Igf2/MPR gene: a model for all gametic imprinted genes? D. P. Barlow; Index.