Diagnostic Pediatric Hematopathology

Diagnostic Pediatric Hematopathology is unique in providing an accurate and up-to-date guide to the diagnosis of benign and malignant hematologic disorders of childhood. The text discusses the development of the hematopoietic and lymphoid systems - and how this affects normal and abnormal findings in children at various ages. Also examined are the morphologic, immunophenotypic, cytogenetic, and molecular genetic characteristics of most pediatric-specific hematologic diseases. This is an excellent reference that ensures accurate diagnoses when evaluating peripheral blood, bone marrow, and lymph nodes of children. The text is written by a team of experienced pediatric hematopathologists and clinical scientists drawn from major academic children's hospitals in the United States, Europe, and Canada. It will be a valuable tool in the every day practice of pathologists, pediatric pathologists, and hematopathologists, and a ready educational resource for fellows, pathology residents, medical students, clinical scientists in the field, and pediatric hematologists/oncologists. '... a very manageable total number of pages ... I found it not to be a weighty tome thus lending itself to be taken from the [shelf] and frequently read ... this volume ... succeeds where many have previously failed in that it provides a true authoritative diagnostic guide to benign and malignant childhood blood disorders ... remarkably clear layout ... copiously illustrated ...' Owen P. Smith, Chair of Haematology, Trinity College DublinIntroduction Maria A. Proytcheva; Part I. General and Non-Neoplastic Hematopathology: 1. Hematologic values in the healthy fetus, neonate, and child Maria A. Proytcheva; 2. Normal bone marrow Maria A. Proytcheva; 3. Disorders of erythrocyte production: nutritional deficiencies, iron deficient, and sideroblastic anemia Angela E. Thomas and Barbara J. Bain; 4. Disorders of hemoglobin synthesis: thalassemias and structural hemoglobinopathies Alexander Kratz and Jeffrey Jhang; 5. Hemolytic anemias: immune- and non-immune-mediated hemolytic anemias, RBC membrane defects, and hereditary disorders due to RBC enzyme defects Suresh G. Shelat; 6. Inherited and acquired bone marrow failure syndromes associated with multiple cytopenias Sa A. Wang and Victor Zota; 7. Inherited bone marrow failure syndromes and acquired disorders associated with single peripheral blood cytopenia: pure red cell aplasia, agranulocytosis, and thrombocytopenias Maria A. Proytcheva; 8. Peripheral blood and bone marrow manifestations of metabolite storage diseases Andrea M. Sheehan; 9. Reactive lymphadenopathies Maria A. Proytcheva; Part II. Neoplastic Hematopathology: 10. Chromosome abnormalities of hematologic malignancies: a practical guide to cytogenetic analysis Katrin Carlson Leuer; 11. Expression profiling in pediatric acute leukemias Lawrence Jennings and Chiang-Ching Huang; 12. Myeloproliferative neoplasms Robert B. Lorsbach; 13. Myelodysplastic/myeloproliferative neoplasms John Kim Choi; 14. Myelodysplastic syndromes and therapy-related myeloid neoplasms Sa A. Wang; 15. Acute myeloid leukemia and related precursor neoplasms Robert B. Lorsbach; 16. Hematologic abnormalities in individuals with Down syndrome John Kim Choi; 17. Precursor lymphoid neoplasms Mihaela Onciu; 18. Advances in prognostication and treatment of pediatric acute leukemia Stanley Chaleff; 19. The effect of chemotherapy, detection of minimal residual disease, and hematopoietic stem cell transplantation Maria A. Proytcheva; 20. Pediatric small blue cell tumors metastatic to the bone marrow Maria A. Proytcheva; 21. Pediatric mature B-cell non-Hodgkin lymphomas Sherrie L. Perkins; 22. Pediatric mature T-cell and NK-cell non-Hodgkin lymphomas Sherrie L. Perkins; 23. Hodgkin lymphoma Mihaela Onciu; 24. Immunodeficiency-associated lymphoproliferative disorders: congenital immune deficiencies, acquired immune deficiencies, and post-transplant lymphoproliferative disorders Mihaela Onciu and J. Han van Krieken; 25. Histiocytic proliferations in childhood Ronald Jaffe; 26. Cutaneous and subcutaneous lymphomas in children Kenneth Chang, Elena Pope and Glen Taylor.