Cognitive Impairment in Schizophrenia

Although the precise mechanisms and pathways of schizophrenia remain something of a mystery, there is little dispute that cognitive deficits present as some of the clearest and most debilitating symptoms of the disease. This book describes the characteristics of cognitive deficits in schizophrenia, functional implications, the course of impairments, the genetic and biological contributions and reviews management options, including neuropsychological, psychological and pharmacological techniques. Chapters are written by leading experts in the field, in an accessible and highly informative style, ensuring the content is clinically relevant. State-of-the-art information about new developments in the treatment of related features of the illness, such as disability, is provided. The wide ranging focus of this volume will appeal to clinicians and academic researchers working with patients impaired by severe mental illness.Preface; Part I. Characteristics of Cognitive Impairment in Schizophrenia: 1. Cognition in schizophrenia as a central illness feature R. Walter Heinrichs, Ashley A. Miles, Narmeen Anmari and Eva Muharib; 2. The multi-faceted, 'global' cognitive impairment profile in schizophrenia Dwight Dickinson, Jonathan Schaefer and Daniel R. Weinberger; 3. Comparative impairments across schizophrenia and bipolar disorder Christopher R. Bowie, Katherine Holshausen and Maya Gupta; 4. Cognitive impairment and symptom dimensions in psychosis Manuela Russo, Robin Murray and Abraham Reichenberg; Part II. Functional Implications and Course: 5. Neurocognition and functional outcome in schizophrenia: filling in the gaps Michael F. Green, William P. Horan, Kristopher I. Mathis and Jonathan K. Wynn; 6. Cognition and work functioning in schizophrenia Susan McGurk and Kim Mueser; 7. Cognition and functional status in adult and older patients with schizophrenia Sara J. Czaja and David Loewenstein; 8. Social cognition and its relationship to neurocognition Amy E. Pinkham; 9. Cognitive functioning and awareness of illness in schizophrenia: a review and meta-analysis Akshay Nair, Andre Aleman and Anthony S. David; Part III. Genetic and Biological Contributions to Cognitive Impairment: 10. Genetic influences on cognition in schizophrenia Katherine E. Burdick, Benjamin Glicksberg and Gary Donohoe; 11. Neurobiological determinants of cognition Daniel C. Javitt; 12. Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches towards understanding cognitive defects Alan Anticejic, John H. Krystal and Deanna M. Barch; Part IV. Assessment and Treatment of Cognitive Impairment and Related Features: 13. Assessment of cognition in schizophrenia treatment studies Richard Keefe; 14. Performance-based measures of functioning in schizophrenia Colin A. Depp, Laura Vergel de Dios, Brent Mausbach and Thomas Patterson; 15. Pharmacological approaches to cognitive enhancement Philip D. Harvey; 16. Computerized cognitive training in schizophrenia: current knowledge and future directions Melissa Fisher, Karuna Subramaniam, Rogerio Panizzutti and Sophia Vinogradov; Index.