Autonomic Failure

This fifth edition of the Autonomic Failure covers the many recent advances made in our understanding of the autonomic nervous system. There are numerous new chapters and extensive revisions of all other contributions. This volume makes diagnosis increasingly precise by fully evaluating the underlying anatomical and functional deficits, thereby allowing more effective treatment. It continues to provide a rational guide to aid in the recognition and management of autonomic disorders for practitioners from a variety of fields, including neurology, cardiology, geriatric medicine, diabetology, and internal medicine.Introduction ; Historical perspectives on the autonomic nervous system ; 1. Neurobiology of the autonomic nervous system ; 2. Molecular genetics and the autonomic nervous system ; 3. Neurotransmitters and neuromodulators in the CNS and cardiovascular regulation ; 4. Adrenergenic and cholingeric receptors ; 5. Structural and chemical organization of the autonomic nervous system with special reference to non-adrenergic, non-cholinergic transmission ; 6. Autonomic and neurohormonal control of the cerebral circulation ; 7. Functional neuroimaging of autonomic control ; 8. Vestibular system influences on respiratory muscle activity and cardiovascular functions ; 9. Autoregulation and autonomic control of the cerebral circulation: implications and pathophysiology ; 10. Temperature regulation and the autonomic nervous system ; 11. Mechanisms underlying complex regional pain syndrome: Role of the sympathetic nervous system ; 12. Autonomic control of the airways ; 13. The gut and the autonomic nervous system ; 14. Nausea, vomiting, and the autonomic nervous system ; 15. The influence of the autonomic nervous system on metabolic function ; 16. The kidney and the sympathetic nervous system ; 17. Neural control of the urinary bladder ; 18. Investigation and treatment of sexual dysfunction in autonomic diseases ; 19. Investigation of autonomic disorders ; 20. Measurement of heart rate and blood pressure to evaluate disturbances in neurocardiovascular control ; 21. Computer analysis of blood pressue and heart rate variability in subjects with normal and abnormal autonomic cardiovascular control ; 22. Central nervous control of cardiovascular system ; 23. Exercise-induced hypotension in autonomic disorders ; 24. Postprandial hypotension in autonomic disorders ; 25. Intraneural recordings of normal and abnormal sympathetic activity in humans ; 26. Pupil abnormality in autonomic disorders: detection and occurrence ; 27. Assessment of sleep disturbances in autonomic failure ; 28. Evaluation of sudomotor function ; 29. Investigation and treatment of bladder dysfunction in diseases affecting the autonomic nervous system ; 30. Biochemical investigation of autonomic function: measurement of catecholamines and metabolites, and the use of spillover and allied techniques to determine regional sympathetic activation ; 31. Autonomic function and the gastrointestinal tract ; 32. Treatment of hyperhidrosis ; 33. Vestibular and autonomic interaction ; 34. Cardiovascular effects of water ingestion ; 35. Clinical features and evaluation of the primary chronic autonomic failure syndromes ; 36. Neuroimaging in autonomic failure syndromes ; 37. Autonomic ganglia and preganglionic neurones in autonomic failure ; 38. Management of postural hypotension ; 39. Treatment of the motor disorders of multiple system atrophy ; 40. Parkinson's disease and autonomic failure ; 41. Development of Parkinson's disease-related pathology in the enteric and central nervous systems ; 42. Neuropathology of multiple system atrophy ; 43. Experimental models to define multiple system atrophy and autonomic failure ; 44. Familial dysautonomia ; 45. Autonomic failure in diabetes ; 46. Dopamine-beta-hydroxylase deficiency: with a note on other genetically determined causes of autonomic failure ; 47. Autonomic dysfunction in peripheral nerve disease ; 48. Autoimmune and paraneoplastic autonomic neuropathies ; 49. Hereditary amyloid neuropathy ; 50. Introduction to neurocardiology ; 51. Transient loss of consciousness ; 52. Syncope and fainting: classification and pathophysiological basis ; 53. Neurally mediated syncope ; 54. Paediatric aspects of neurally mediated syncope ; 55. Pain and the sympathetic nervous system: pathophysiological mechanisms ; 56. Sympathetic neural mechanisms in hypertension ; 57. Postural orthostatic tachycardia syndrome ; 58. Circulatory shock ; 59. Autonomic disturbances in spinal cord lesions ; 60. Situational syncope ; 61. Cardiac causes of syncope ; 62. Cardiac failure and the autonomic nervous system ; 63. Autonomic disorders affecting cutaneous blood flow ; 64. Autonomic aspects of migraine: pathophysiology and treatment ; 65. Drugs, chemicals, and toxins that alter autonomic function ; 66. Ageing and the autonomic nervous system ; 67. Surgery and the autonomic nervous system ; 68. Autonomic Surgical Neuroanatomy ; 69. Phaeochromocytoma: a clinical chameleon