Stem Cells in Human Reproduction

Stem cell science has the potential to impact human reproductive medicine significantly - cutting edge technologies allow the production and regeneration of viable gametes from human stem cells offering potential to preciously infertile patients. Written by leading experts in the field Stem Cells in Reproductive Medicine brings together chapters on the genetics and epigenetics of both the male and female gametes as well as advice on the production and regeneration of gene cells in men and women, trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a section on new developments in stem cell research. The book is essential reading for reproductive medicine clinicians, gynecologists and embryologists who want to keep abreast of practical developments in this rapidly developing field.Preface; Foreword: views from a pioneer Alan Trounson; Part I. Female Gamete: 1. Genetics of the germline formation Orkan Ilbay and Emre Seli; 2. Germ cell differentiation from pluripotent cells Jose V. Medrano, Ana M. Martinez-Arroyo, Carlos Simon and Renee A. Reijo Pera; Part II. Male Gamete: 3. The male gamete Nicolas Garrido, Rocio Rivera and Marcos Meseguer; 4. In vitro production of functional sperm from neonatal mouse testes Takehiko Ogawa; 5. Adult stem cell population in the human testis Ellen Goossens and Herman Tournaye; Part III. The Embryo/Blastomere: 6. Meiotic recombination in human oocytes Jennifer R. Gruhn, Karl W. Broman, Patricia A. Hunt and Terry J. Hassold; 7. Gene expression dynamics during human embryonic development Carlos Simon and Renee A. Reijo Pera; 8. Embryonic stem cells from blastomeres maintaining embryo viability Irina Klimanskaya; 9. Gamete generation from stem cells to avoid gamete donation and customized hESC from blastomeres as the cellular insurance for the newborn: will it ever be ethically acceptable? Heidi Mertes and Guido Pennings; Part IV. Trophoblast, Amniotic Fluid, Endometrium and Bone Marrow: 10. Amniotic fluid and placental membranes: unexpected sources of highly multipotent cells Sean Vincent Murphy and Anthony Atala; 11. Adult stem cells in the human endometrium Caroline E. Gargett, Irene Cervello, Hong P. T. Nguyen and Carlos Simon; 12. In utero hematopoietic cell transplantation Amar Nijagal and Tippi C. MacKenzie; 13. Bone marrow stroma: a source of mesenchymal stem cells for cell therapy Agustin G. Zapata; Part V. New Developments in Stem Cell Research: 14. Dedifferentiation, transdifferentiation and reprogramming Sergio Mora and Angel Raya; 15. The metabolic framework of pluripotent stem cells and potential mechanisms of regulation Alexandra J. Harvey, Joy Rathjen and David K. Gardner; Index.