Fed-Batch Cultures

Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.1. Introduction to fed-batch bioreactors; 2. Idealised reactors and fed-batch reactors; 3. Maximisation of reaction rates and fed-batch operation; 4. Phenomena that favour fed-batch operations; 5. Classification and characteristics of fed-batch cultures; 6. Models based on mass balance equations; 7. Non-equation-based models; 8. Experimental determination of specific rates; 9. Optimization via Pontryagin's maximum principle; 10. Computational techniques; 11. Optimization of single and multiple isothermal reactions; 12. Optimization of fed-batch cultures for cell mass production; 13. Optimization of fed-batch cultures for metabolites; 14. Simple, intuitive adaptive optimization; 15. Measurements, estimation and control; 16. Feasibility assessment and implementable feed rates.