Non-Motor Symptoms of Parkinson's Disease

Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research. Review from previous edition ...this is a valuable reminder that there are many non-motor symptoms that can be just as distressing. BMA Medical Book CompetitionSECTION 1 NMS: GENERAL CONCEPTS ; 1. What are the non-motor symptoms of Parkinson's disease? ; 2. Non-motor symptoms and pre-motor diagnosis of Parkinson's disease ; 3. Non-motor symptoms in the early motor stages of Parkinson's disease ; 4. Non-motor symptoms in advanced Parkinson's disease ; 5. Assessment tools for non-motor symptoms of Parkinson's disease in the clinical setting ; 6. Imaging non-motor aspects of Parkinson's disease ; 7. Non-motor signs in genetic forms of Parkinson's disease ; SECTION 2: SPECIFIC NMS OF PD ; 8. Cognitive dysfunction of Parkinson's disease ; 9. Depression, anxiety and apathy in Parkinson's disease ; 10. Dementia in Parkinson's disease ; 11. Fatigue in Parkinson's disease ; 12. Psychosis in Parkinson's disease ; 13. Neurobiology of sleep: The role of dopamine in Parkinson's disease related sleep disorders ; 14. REM sleep behaviour disorder in Parkinson's disease ; 15. Parkinson's disease and restless legs syndrome ; 16. Excessive daytime sleepiness in Parkinson's disease ; 17. Bladder dysfunction in Parkinson's disease ; 18. Sexuality in Parkinson's disease ; 19. Gastrointestinal dysfunctions in Parkinson's disease ; 20. Postural hypotension in Parkinson's disease ; 21. Sialorrhoea in Parkinson's disease ; 22. Olfaction in Parkinson's disease ; 23. Chronic pain and Parkinson's disease ; 24. Visual function in Parkinson's disease ; SECTION 3: QUALITY OF LIFE, COMORBIDITY, DRUG EFFECTS AND SURGERY ; 25. Non-motor symptoms and health-related quality of life: an overview ; 26. Non motor symptoms and co-morbidity in Parkinson's disease ; 27. Non-motor symptoms of Parkinson's disease and the effects of deep brain stimulation surgery ; 28. Impulse dyscontrol and dopamine dysregulation syndrome ; 29. Treatment-related non-motor symptoms in Parkinson's disease ; 30. Thermoregulatory dysfunction in Parkinson's disease ; 31. The role of continuous dopaminergic stimulation in the management of non-motor symptoms in Parkinson's disease