Treatment of Neurodevelopmental Disorders

This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment. "Every clinician who cares for children and adolescents has some patients with the neurodevelopmental problems described here. This book provides an excellent overview of the neuroscientific research that guides the evaluation and treatment of these disorders as well as in-depth information on each one. Treatment of Neurodevelopmental Disorders should be in the reference library of every clinician who evaluates and treats children." --Catherine DeAngelis, MD, MPH, University Distinguished Service Professor and Professor of Pediatrics, Emerita, The Johns Hopkins University School of Medicine;Editor-in-Chief Emerita, JAMA"This book unequivocally demonstrates there is new hope for targeted medical treatments for children with known neurodevelopmental disorders. It reviews recent breakthroughs and explains the underlying neurobiology. It fills an important gap by specifying the most recent advances in treatment and their translation to the clinic. I highly recommend it as an invaluable resource for physicians, educators, and members of all disciplines involved in providing care for children with neurodevelopmental disorders and their families." --James C. Harris, MD, Director of Developmental Neuropsychiatryand Professor of Psychiatry and Behavioral Sciences, Mental Health and Pediatrics, The Johns Hopkins University School of MedicineChapter 1 ; Overview of Neurodevelopmental Processes and the Assessment of Patients with Neurodevelopmental Disorders ; Robert Hendren, Andre Goldani, Randi Hagerman ; Chapter 2 ; Autism: Neurobiologic Mechanisms and Targeted Treatments ; Robert Hendren and Randi Hagerman ; Chapter 3 ; Targeted Treatments in Schizophrenia ; Danielle A. Schlosser, Coleman Garrett, Sophia Vinogradov ; Chapter 4 ; Neurodevelopmental and Neurobiological Aspects of Major Depressive Disorder: ; From Theory to Therapy ; Blake Rawdin, Daniel Lindqvist, Nicole Bush, Steven Hamilton, Ruhel Boparai, Scott Mackin, Victor I. Reus, Synthia H. Mellon, Owen M. Wolkowitz ; Chapter 5 ; Attention Deficit Hyperactivity Disorder ; Kyle J. Rutledge, Khyati Brahmbhatt, Julie Schweitzer ; Chapter 6 ; Targeted Treatments in Rett Syndrome ; Daniel C. Tarquinio, Walter E. Kaufmann ; Chapter 7 ; Cardio-facio-cutaneous Syndrome and other RASopathies: Prospects for Treatment ; William E. Tidyman and Katherine A. Rauen ; Chapter 8 ; Targeted Treatments in Tuberous Sclerosis Complex (TSC) ; Petrus J de Vries ; Chapter 9 ; Treatment of Fragile X syndrome and Fragile X-associated Disorders ; Reymundo Lozano, Emma B. Hare, Randi J. Hagerman ; Chapter 10 ; Angelman Syndrome ; Mary Jacena Leigh, Lindsey Partington, Edwin Weeber ; Chapter 11 ; Pharmacotherapy for Cognitive Enhancement in Down Syndrome ; Aarti Ruparelia, David Patterson, William C. Mobley ; Chapter 12 ; Targeted Treatments for Phenylketonuria ; Billur Moghaddam ; Chapter 13 ; Muscular Dystrophies: Diagnosis and New Treatments ; Bethany M Lipa, Que T. Nguyen, Jay J. Han ; Chapter 14 ; Translating Treatments from the Laboratory to the Clinic ; Randi Hagerman, Billur Mogahadam, Jan Nolta, Maria Diez, Robert Hendren ; Index