Neuropathology of Neurodegenerative Diseases Book and Online

This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases. The book is packaged with a password, giving the user online access to all the text and images. Advance praise: 'Neuropathology of Neurodegenerative Diseases: A Practical Guide edited by Gabor Kovacs is a highly recommended book, written from the perspective of both neuropathologist and clinician. This practical guide is comprehensively updated with the most recent morphological and genetic advancements in the differential diagnoses of neurodegenerative diseases. The supreme author team introduces the core concept of neurodegenerative disorders and guides the reader systematically from the basic practical approach in sampling of brain tissue, histological staining, and molecular methods toward clinical-pathological description of specific proteinopathy. With its extensive combination of masterfully edited text, easy-to-read tables, graphs and high-quality illustrations, this practical guide makes learning and reading of neurodegenerative disorders easy and enjoyable.' Nenad Bogdanovic, Oslo University and Karolinska Institutet, StockholmList of contributors; 1. Introduction: classification of neurodegenerative diseases Gabor G. Kovacs; 2. Clinical aspects of dementia Erin C. Golden and Keith A. Josephs; 3. Clinical aspects of movement disorders Walter Pirker; 4. Ethical, health and safety considerations James W. Ironside; 5. Practical approach to diagnosis: sampling and basic stainings Gabor G. Kovacs; 6. Molecular methods Isidro Ferrer; 7. Alzheimer's disease Charles Duyckaerts; 8. Tauopathies Gabor G. Kovacs; 9. Synucleinopathies Irina Alafuzoff, Maria Pikkarainen and Laura Parkkinen; 10. Human prion diseases James W. Ironside, Diane L. Ritchie, Alexander H. Peden and Mark W. Head; 11. Neurodegenerative diseases linked to trinucleotide repeats Charles Duyckaerts, Natacha Joyon and Alexandra Durr; 12. Amyotrophic lateral sclerosis and frontotemporal lobar degeneration Tibor Hortobagyi and Nigel J. Cairns; 13. Other NDG conditions I: hereditary cerebral amyoid angiopathies Ruben Vidal and Bernardino Ghetti; 14. Other NDG conditions II: familial encephalopathy with neuroserpin inclusion bodies Ruben Vidal and Bernardino Ghetti; 15. Other NDG conditions III: hereditary ferritinopathies Ruben Vidal and Bernardino Ghetti; 16. Other NDG conditions IV: neurodegeneration with brain iron accumulation Isidro Ferrer; 17. Concomitant pathologies I: cerebrovascular diseases Isidro Ferrer; 18. Concomitant pathologies II: neurodegenerative conditions Gabor G. Kovacs, Isidro Ferrer and Irina Alafuzoff; Appendix A. Molecular classification of frontotemporal lobar degeneration (FTLD) with genetic correlations Gabor G. Kovacs and Nigel J. Cairns; Appendix B. Scheme for evaluation of frontotemporal lobar degeneration (FTLD) Gabor G. Kovacs and Nigel J. Cairns; Index.