Neuroprogression and Staging in Bipolar Disorder

After the original proposals of staging for psychotic disorders developed by McGorry and colleagues, a few systems have been put forward specifically for people with bipolar disorder. There is now consistent evidence that, at least for a significant portion of people with this disease, clinical course and outcome are not as benign as initially described. The evidence thus far points to relevant differences between early and late stages of bipolar disorders in the clinical course of illness, neurobiology and systemic pathology. These differences all suggest that staging is a viable addition to clinical care in bipolar disorder. Neuroprogression and Staging in Bipolar Disorder provides a comprehensive summary of the current state of the evidence regarding the use of staging systems in bipolar disorder. Edited by the leading researchers in the field, the book systematically covers the theoretical basis for staging, comparisons between different proposals, neurobiological underpinnings, the current evidence-base, limitations and future directions, and clinical implications and recommendations for practice. The book provides a solid and in-depth outline and thus to influence research and practice in the field of bipolar disorder. This is an intriguing book about the staging of bipolar disorder and about viewing the disorder as a progressive illness with biological and treatment implications as the illness advances. It would be useful for any clinicians or researchers involved in treating patients with this all too frequently occurring illness. Michael Joel Schrift, DO, MA (Northwestern University Feinberg School of Medicine), Doodys NotesForeword ; 1. Clinical staging in bipolar disorder: a historical perspective ; 2. Staging systems in bipolar disorder ; 3. Allostatic load and accelerated aging in bipolar disorder ; 4. Neuroprogression as the biological underpinning of staging in bipolar disorder ; 5. Functioning and illness progression in bipolar disorder ; 6. Cognition and illness progression in bipolar disorder ; 7. Social cognition and staging in bipolar disorder ; 8. Affective temperaments: potential latent stages of bipolar disorders ; 9. Neuroimaging and illness progression ; 10. Biomarkers in illness progression in bipolar disorder ; 11. Childhood adversity and illness progression in bipolar disorder ; 12. Vascular and Metabolic Medical Comorbidities and Neuroprogression in Bipolar Disorder ; 13. Substance misuse in staging bipolar affective disorder ; 14. Excellent lithium responders, resilience and staging in bipolar disorder ; 15. Staging and early intervention in bipolar disorder ; 16. Pharmacological treatment of late-stage bipolar disorder ; 17. Illness progression and psychosocial interventions in bipolar disorder ; 18. Staging systems in bipolar disorder: current findings, future directions and implications for clinical practice