Foundations of Clinical Research

Foundations of Clinical Research: Applications to Practice, 3/e serves as a comprehensive reference for a variety of research situations. This edition reflects the contemporary focus on evidence-based practice in health care, and the essential concepts for understanding analysis and research design. Expanded topics include measures of diagnostic accuracy, statistical estimates of validity and reliability, systematic reviews and meta-analysis, search strategies and critical appraisal of literature for clinical decision making and development of research. Written for those in the health professions, including physical therapy, occupational therapy, speech therapy, nursing, and exercise physiology, this text will be useful to developing clinicians, practitioners, graduate students and researchers.Part I: Foundations of Clinical Research 1. A Concept of Clinical Research 2. The Role of Theory in Clinical Research 3. Ethical Issues in Clinical Research Part II: Concepts of Measurement 4. Principles of Measurement 5. Reliability of Measurements 6. Validity of Measurements Part III: Designing Clinical Research 7. Asking the Research Question 8. Sampling 9. Validity in Experimental Design 10. Experimental Designs 11. Quasi-Experimental Designs 12. Single Subject Designs 13. Exploratory Research: Observational Designs 14. Descriptive Research 15. Surveys and Questionnaires 16. Systematic Reviews and Meta-Analyses Part IV: Data Analysis 17. Descriptive Analysis 18. Statistical Inference 19. Comparing Two Means: The t-test 20. Comparing More Than Two Means: Analysis of Variance 21. Multiple Comparison Tests 22. Nonparametric Tests for Group Comparisons 23. Correlation 24. Regression 25. Measures of Association for Categorical Variables: Chi-Square 26. Statistical Measures of Reliability 27. Statistical Measures of Validity 28. Epidemiology: Measures of Risk 29. Multivariate Analysis 30. Data Management